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Factor V Leiden and factor VIII levels
Started by Feelgood
Posted: July 22, 2008 at 09:55
The association between high factor VIII:C levels and venous thrombosis has been confirmed in several independent studies.
There are several studies reporting that high levels of factor VIII are associated with an increased risk of recurrences of thrombosis.

To have blood types A, B, or AB puts a person at higher risk for deep vein thrombosis (DVT) or pulmonary embolism (PE) than to have blood type O. The people with blood types A, B, or AB have about double the risk for DVT and PE than people with blood type O. This is probably mostly due to people with blood type A, B and AB having higher factor VIII levels than people with blood type O; and high factor VIII levels are a known risk factor for DVT and PE.

So people with blood types A, B, and AB have a higher risk for DVT PE than people with blood type O, and having factor V Leiden at the same time increases the risk for clots even further.

Elevated Factor VIII Levels and the Risk of Thrombosis:
http://atvb.ahajournals.org/cgi/content/full/atvbaha;21/5/731

Synergism between non-O blood group and risk of venous thromboembolism:
http://www.hal.inserm.fr/docs/00/23/19/73/PDF/Letter_R1_v1.pdf

Other Determinants of Plasma Factor VIII Levels are:

Body mass index (positively correlated with factor VIII levels) and higher levels of glucose (diabetes mellitus), insulin, fibrinogen, and triglycerides are also associated with increased factor VIII levels. Factor VIII levels increase with age, with an average rise of 5 to 6 IU/dL per decade.

Levels can also increase as the result of strenuous exercise or the administration of several drugs including epinephrine, DDAVP, or estrogen (for birth control or hormone replacement therapy). Sustained rises in factor VIII are seen during pregnancy, surgery, chronic inflammation, malignancy, liver disease, hyperthyroidism, intravascular hemolysis, and renal disease. In most conditions, there is a concordant increase of factor VIII and vWF:Ag levels.

Elevation of factor VIII above 150% is associated with an increased risk for venous thrombosis of more than fivefold.

-- VTE Risk Declines With Greater Intake of Fish, Fruit, and Vegetables --

The effects of certain food choices on health may increase the risk for venous thromboembolism (VTE), according to an analysis of prospectively collected data from the Atherosclerosis Risk in the Community (ARIC) study. Based on 12 years of observation of thousands of adults in 4 US states, the study suggests that a diet rich in fruits, vegetables, and fish can lower VTE risk while one high in red meat raises it.

In this first study to explore the relationship between diet and incident VTE risk, according to lead author Lyn M. Steffen, MD, from the University of Minnesota School of Public Health, Minneapolis, a "threshold effect" was observed for fish intake while intake of specific nutrients showed a "dose-response" risk relationship. "Eating at least one serving of fish per week was associated with a lower risk of VTE and eating more fish or omega-3 fatty acids did not change this," she told heartwire. "But when examining the relation between vitamin B6 and risk of incident VTE, the risk was lower with each increasing quintile of B6 intake."

The VTE risk declined with rising fruit and vegetable intake (P = .03 for trend across quintiles of increasing consumption) and decreased 30% to 45% for fish intake of about 1 serving per week or more compared with the lowest intake quintile. The risk rose significantly with increasing intake of "red or processed meat" (P = .02 for trend), doubling at intakes of more than 10.5 servings per week compared with less than 3.5 servings per week.

The VTE risk was reduced by one third to one half for persons who reported folate consumption at of 160 g/day or more, and by 30% to 46% for those consuming at least 0.1 g/day omega-3 fatty acids in both cases, quintiles 2 through 5 compared with the first quintile. The risk declined steadily with rising intake of vitamin B6 (P = .007 for trend) and appeared unrelated to saturated fatty acid intake.

"Surprisingly, whole grain foods, good sources of folate and vitamin B6, were not related to VTE risk," according to the current authors.

http://www.medscape.com/viewarticle/549935
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Re: Factor V Leiden and factor VIII levels
Reply #1 by Char
Posted: July 22, 2008 at 13:24
Interesting subjects, my Sister type O has been tested for V Leiden and APS, negative results. I am type A, 2 of my 3 kids report they are type A; the third one is not sure. I eat no red meat, at least for the last 20 years, modest amounts of fruit and veggies. But if it is genetic those facts may not be an issue. My Mother ate mostly fruit, veggies, fish and poultry. She was heavy and a smoker, I am a non-smoker and thin, I was informed it does not matter when it is genetic. But DVT happened to my Mother at a much younger age. Not sure if it was her lifestyle as her Mom, non-smoker had DVT at a young age.
I had some serious surgery in 2002, now I wonder if I had asymptomatic DVT, as I just did not feel good. Had serious left groin pain, had many Ultrasounds and CT's with contrast, all negative. Have damaged veins in my left leg, but not as serious as my right leg, my Feb DVT was in my right leg. No swelling in either calf at those time periods, breathing problems since 2002. Chest x-rays negative, but x-rays do not show the whole story.
Very interested in your topics, complicated and will I ever find the genetic cause.

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Re: Factor V Leiden and factor VIII levels
Reply #2 by terry
Posted: January 24, 2011 at 05:34
can i lower my factor v111 levels with nutrients or is it genetic and
therfor determined my level is 259 iu/dl and i suffered a dvt in september 2010
19881
Re: Factor V Leiden and factor VIII levels
Reply #3 by mindelei
Posted: August 2, 2013 at 03:39
Link to the first article has changed:
http://atvb.ahajournals.org/content/21/5/731.full.pdf+html?sid=a6c09d27-
eb5d-4206-9cc9-f61b93e143e7
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