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D-dimer tests
Started by NB
Posted: April 25, 2007 at 14:07
Does anyone have any experience of d-dimer testing in relation to DVT ?

I was given a d-dimer test as part of my initial DVT diagosis - after the 2nd positive d-dimer they agreed for me to have an ultrasound scan of my leg. I have since read quite a lot about d-dimers in Research papers etc and there is some literature which points towards d-dimer measurement being a useful indicator of DVT recurrence.

Now that I'm off warfarin (after 6 month course) I pursuaded my GP to send me for a repeat d-dimer. Its come back positive again, although at a lower level then when I had my DVT diagnosis. He has suggested that I have another d-dimer in June but I am likely to be back on warfarin by then, as i am temporarily off while have my thrombophilia tests done.

Does anyone know if d-dimer readings can be affected by warfarin (coumadin) - my GP was a little bit vague on this(!. I would also be interested in whether any of you have been having regular d-dimer tests or know any more about how useful an indicator this is.
Re: D-dimer tests
Reply #1 by Di
Posted: April 26, 2007 at 01:15
I just had my second post-warfarin D-Dimer test today. I had the first two days after going off warfarin, while it was still in my system. That one was negative. Now that I have been off warfarin a full month, they tested me again. With any luck it is still low and I will stay off warfarin.

I previously thought the results were not valid if you were on warfarin, but the doctor had me take the test anyway, so now I'm not sure.
Re: D-dimer tests
Reply #2 by NB
Posted: April 27, 2007 at 20:20
I found out today that warfarin lowers the d-dimer result, so its better really to not be on warfarin when tested. I guess an expert would be still be able to interpret the result if you were on warfarin, but it makes it more complex.

The same expert told me that its early days regarding the use of d-dimer as a predictive tool into risk of recurrence, as not many studies had been completed, but that it is 'promising' as a tool in the future.
Re: D-dimer tests
Reply #3 by fran
Posted: April 14, 2012 at 23:45
im on warfarin 4 mg and had a normal d dimer result
Re: D-dimer tests
Reply #4 by CJ
Posted: April 17, 2012 at 08:32
I had a D-Dimer blood test to see if i had a blood clot in my leg which came back negative twice so they said i never had a clot the next day they scanned me and i was found to have a DVT. D-dimers are not accurate enough giving false negative readings.
Re: D-dimer tests
Reply #5 by Shaun
Posted: May 7, 2014 at 06:42
Scan's aren't definitive for new DVT neither so which test is correct?
Re: D-dimer tests
Reply #6 by Dr. Adrian Kruit
Posted: December 15, 2014 at 03:58
A negatieve D-dimer test will rule out a DVT with nearly 100%
certainty when the pre-test probability is low. IN other words, if there
are no obvious signs for DVT and the test comes back negative. On
the other hand, when a DVT is likely, a negative D-dimer will not rule
it out nor will a positive D-dimer test in light of nonspecific
symptoms for DVT/PE confirm the diagnosis.
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