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Lovenox and liver enzymes
Started by Rick
Posted: December 11, 2008 at 18:37
I had to be taken off Lovenox last week because
my liver enzymes continued to elevate. Put on Arixtra
until INR gets back to 2-3 range.
If it helps anyone else although its rare...make sure your
doctor checks your liver enzymes while on Lovenox.
Within a few days my levels have come back down to normal range.

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Re: Lovenox and liver enzymes
Reply #1 by Rick
Posted: December 11, 2008 at 18:42
Meant to say I was put on Arixtra and Coumadin.
2.1 today so off the Arixtra.

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Re: Lovenox and liver enzymes
Reply #2 by John in Dallas
Posted: December 12, 2008 at 11:36
Hmmm,

I was on Arixtra after having a bad bout with Lovenox and Coumadin. The way I understand it is that Arixtra is a pentasaccharide and comes out via the kidneys in the same form it was injected. Hence no lver involement. I had horrible side reactions to lovenox as well as coumadin. Did you have any reactions to lovenox and now that you are just on coumadin do you have any? Just curious because Coumadin was just horrid for me and I went to Arixtra for the course of my anticoagulant treatment because of the side reactions.
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Re: Lovenox and liver enzymes
Reply #3 by Hi John
Posted: December 12, 2008 at 16:11
Today is my first day on Coumadin only. While on Lovenox my energy
level was just plain aweful. Felt kinda sick most of the time.
Within just a few days of being taken off Lovenox my liver enzyme
levels are back to just about normal levels.
I'll be on Coumadin for 3-6 months so I'll let you know how I do.
Some of my symtoms when I was first put on Coumadin may have been
related to anxiety issues I was having after being diagnosed with the
two clots. My doctor also believes the anxiety caused me to suffer
from IBS. It's been a very challenging 2 1/2 months.
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Re: Lovenox and liver enzymes
Reply #4 by Kathy
Posted: December 20, 2008 at 03:26
I am 5 months pregnant and I am taking 60 mg of lovenox am and 40 mg lovenox pm. My liver function blood work has come back very elevated. My doctor just took me off lovenox and wants to see if this is why. He said my GTT was elevated. Any advice?
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Re: Lovenox and liver enzymes
Reply #5 by Khalid
Posted: December 29, 2008 at 10:19
I am on Clexane (Indan brand for Lovenox) for the last 9 months. Would anyone please tell what prompted you to do the liver enzyme test?

Thanks
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Re: Lovenox and liver enzymes
Reply #6 by Char
Posted: December 29, 2008 at 11:27
Hey Khalid, many drugs increase liver enzymes and Lovenox can cause an reversible increase in liver enzymes. Most Doctors monitor for this side effect. It is your Doctors choice to order liver enzyme blood work, probably it is a routine analysis anytime you have had blood work.
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Re: Lovenox and liver enzymes
Reply #7 by Rick
Posted: December 31, 2008 at 22:49
After being on Lovenox for about a month my AST and ALT were
both around 300. One week after being taken off Lovenox my AST and ALT
were 90 and 120. One week later they were 24 and 40...back to where they were before taking Lovenox.
I'll be on Coumadin through the end of April.

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Re: Lovenox and liver enzymes
Reply #8 by David
Posted: July 14, 2009 at 01:06
This is interesting for me as I just had my very first elevated ALT ..it was 110, it has always been around 25... but recently i had to have a colonosopy and i lmust normally keep my INR between 3.0 to 3.5 so they wanted to take me completely off of coumadin and they used lovenox .. my ALT test was taken one day after i came off of lovenox.
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Re: Lovenox and liver enzymes
Reply #9 by rx rph
Posted: September 27, 2009 at 17:10
after being on lovenox for 7 days cholesterol taken as routine. found alt to be 213 and ast 165. have stoped lovenox and increased my coumadin. will let you know if alt and ast drop. rx
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Re: Lovenox and liver enzymes
Reply #10 by Damaris
Posted: October 12, 2010 at 17:39
I am a 47 year old female. I have been on the medication "Coumadin" 10 mg for 17 years, 7 months, and 12 days; since a Mitral Valve replacement with a mechanical heart valve, on March 1, 1993. The only side effects of coumadin that I have experienced have been easy bruising (black & blues), longer scar/scrape healings & longer and heavier menstrual cycles. On March 21, 2010, I had blood work done which included my liver enzyme readings. At that time my liver enzyme readings were pretty much normal. My AST was 36, ALT was 22 and Alkaline Phosphatease 106. On Sept. 25, 2010, my doctor put me on Lovenox and off coumadin for a medical procedure. I was on Lovenox for 16 days. My liver enzymes were checked on Oct.5, 2010 and were very high. I don't remember what the numbers were, but my doctor rechecked it again the following day, Oct. 6, 2010 and he said they were even higher. (Sorry, I don't have those lab numbers either) He asked me if I were taking any vitamins, herbs, supplements, over the counter drugs, anything different during the last 13 days. I asked him if the Lovenox could be elevating my liver enzymes? He paused, thought about it and told me no. So I asked him if it could be my coumadin because I found info that coumadin could raise liver enzymes. Again he said no. So I mentioned a high whey protein that I started taking the same day as my Lovenox and he said whatever that was, to stop taking it and he would recheck it the following Mon. I was affaid and started to think the worst about my Liver. So I went on an organic fruit and vegie diet and started taking Milk Thisel drops three times a day. On Mon. Oct. 11, 2010 I went in for another blood test. The nurse called me on Tuesday morning and told me that the doctor said that the liver enzymes were going down but they were still elevated. The fruit & veggie, and Milk Thisel diet worked somewhat, but not enough to get normal readings. I asked her what the readings were and she told me that the AST was 78, the ALT was 108 and the Alkaline Phosphate was 186. I stopped Lovenox on Monday Oct. 10, 2010 but I took my blood test at 8:30 am that morning. So the medicine is still in my body. The reason I'm writing this is to say what a great relief to know that Lovenox can and does cause High Liver Enzymes. I don't know why my doctor is not aware of this. I'll have to let him know about this website and other people experiencing high liver enzymes with Lovenox use. I will be getting my CMP blood work checked again on, Wed. Oct. 13, 2010. Hopefully I'll get great Liver enzyme readings. I'll let you know.
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Re: Lovenox and liver enzymes
Reply #11 by annabelle
Posted: August 8, 2011 at 22:33
I was on lovenox for one week, and had my liver enzymes checked, they were 10X the normal rate! After being off of lovenox for only three days, these levels were halved. Be aware of the effect lovenox might be having on your liver.
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Re: Lovenox and liver enzymes
Reply #12 by Grateful
Posted: September 16, 2011 at 05:37
I am so glad to have found this site. After total knee replacement on 7/19/11, I developed a DVT and PE 4 wks post surgery. I was put in the hopital for 9 days and was given 10mil of coumadin and two shots of Lovenox daily. I came home and gave myself shots twice daily for 2 weeks and did labs for a contrast CT scan where everything came back normal with the exception of very high AST and ALT levels which I've never had before. I was able to stop the shots last week as my INR went to 2.2 and I have a follow up visit with doc this Monday, 9/19. I will request a repeat of labs as I am now convinced that liver enzymes were elevated as a result of 4 weeks of Lovenox injections. I received a large packet in the hospital explaining the purpose and side effects of Lovenox injections and liver enzymes were not mentioned. I panicked when I received my lab results and am so grateful to have found this site. Thank you all for taking the time to share.
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Re: Lovenox and liver enzymes
Reply #13 by MARTY
Posted: October 26, 2011 at 21:13
Thank you for sharing your experience. I just learned that my liver enzymes are elevated and suspect Lovenox as the cause. I'll notify FDA as this is a dangerous side effect that should be disclosed.
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Re: Lovenox and liver enzymes
Reply #14 by Ken
Posted: December 29, 2011 at 04:43
Coumadin switch to Lovenox prior to medical procedure. INR and Lipids tested same day of
procedure. INR .9 and Alt was 250 compared to consistent readings of mid 20's. Still taking
Lovenox waiting to hear back from coumadin clinic or doctor. Sounds similar to stories
above.
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Re: Lovenox and liver enzymes
Reply #15 by Debbie
Posted: February 18, 2012 at 07:21
I was called today by my drs nurse and told to discontinue all medications
including the coumadin for my deep vein thrombosis. No pain meds either. I
have very painful phlebitis as well as arthritis and fibromyalgia, I asked why,
they said liver function was so bad. I had been on 150 ml injections of lovenox 2
times a day for a week. With your posts I feel alot more reassured. holiday
weekend so I don't see the dr until Tuesday. Thanks
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Re: Lovenox and liver enzymes
Reply #16 by Debbie
Posted: February 18, 2012 at 07:54
I was called today by my drs nurse and told to discontinue all medications
including the coumadin for my deep vein thrombosis. No pain meds either. I
have very painful phlebitis as well as arthritis and fibromyalgia, I asked why,
they said liver function was so bad. I had been on 150 ml injections of lovenox 2
times a day for a week. With your posts I feel alot more reassured. holiday
weekend so I don't see the dr until Tuesday. Thanks
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Re: Lovenox and liver enzymes
Reply #17 by L
Posted: February 18, 2012 at 10:19
My enzymes are raised on both coudamin (warfarin) and Lovenox (clexane)

I am on arixtra now but it doesn't feel it works as well as the clexane.

I am on it for life.
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Re: Lovenox and liver enzymes
Reply #18 by Kevin
Posted: August 21, 2012 at 23:10
This is from RxMed - Exoxaparin = Lovenox = LMWH (Low Mol Wgt Heparin)
"Liver: Transient, asymptomatic elevations of liver transaminases (AST
and ALT) to greater than three times the upper limit of normal has
been observed in up to 6% of patients taking enoxaparin. This is a
consistent finding with all members of the LMWH class, as well as with
unfractionated heparin. The mechanism associated with the increased
levels of liver transaminases has not been elucidated. No consistent
irreversible liver damage has been observed. Transaminase levels
returned to normal within 3 to 7 days after discontinuation of
enoxaparin."
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Re: Lovenox and liver enzymes
Reply #19 by connie times
Posted: November 3, 2012 at 23:22
i started lovenox on 10-19-12 and my alt is high but my ast is to low and i have a itchy rash when i saw my test i got woried reading all these letters made my feel better thanks but i would like to know what does all this do to the liver are we going to have problems later when we no longer on this medecin?
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